B1a B lymphocytes are atheroprotective by secreting natural IgM that increases IgM deposits and reduces necrotic cores in atherosclerotic lesions. Kyaw T, Tay C, Krishnamurthi S, Kanellakis P, Agrotis A, Tipping P, Bobik A, Toh BH. B cells and humoral immunity in atherosclerosis. Tsiantoulas D, Diehl CJ, Witztum JL, Binder CJ. Immune effector mechanisms implicated in atherosclerosis: from mice to humans. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990вЂ“2013: a systematic analysis for the Global Burden of Disease Study 2013. GBD 2013 Mortality and Causes of Death Collaborators. Global overview of the epidemiology of atherosclerotic cardiovascular disease. Barquera S, Pedroza-TobГas A, Medina C, HernГЎndez-Barrera L, Bibbins-Domingo K, Lozano R, Moran AE. Their transfer but not IgG from nonatherosclerotic mice into Ldlr в€’/в€’ mice whose B cells are Blimp-1-deficient increased atherosclerosis transfer was associated with IgG accumulating in atherosclerotic lesions, increased lesion inflammatory cytokines, apoptotic cell numbers, and necrotic core size. To determine the importance of IgG for atherosclerosis, we purified IgG from atherosclerotic mice. Blimp-1-deficient B cells greatly attenuated atherosclerosis and immunoglobulin-including IgG production, preventing IgG accumulation in atherosclerotic lesions Blimp-1 deletion also attenuated lesion proinflammatory cytokines, apoptotic cell numbers, and necrotic core. As FO B cells differentiating into plasma cells require Blimp-1, we also assessed its role in the development of atherosclerosis. During development of atherosclerosis, these deficiencies affected TвЂ“B cell interactions, germinal center B cells, plasma cells, and IgG. Using mixed chimeric Ldlr в€’/в€’ mice whose B cells are deficient in MHCII or CD40, we demonstrate that these molecules are critical for the proatherogenic actions of FO B cells. Customer Service and Ordering Information.Stroke: Vascular and Interventional Neurology.

Journal of the American Heart Association (JAHA).

Circ: Cardiovascular Quality & Outcomes.

Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).

Eliza schneider roger tay